Effect of porous structure of silica carriers and diclofenac state on kinetics of active substance release

Authors

  • R. B. Kozakevych Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • V. V. Yanishpolskii Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • V. A. Tertykh Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine

Abstract

The composites based on diclofenac and silicas with various porosity and particle size have been obtained. The dissolution rate of the crystalline form of diclofenac and its release rate from the silica carriers have been investigated. When impregnating diclofenac into porous silica matrices, the structure of active compound has been found to transform into amorphous state what provides an increase of its dissolution rate. The diclofenac release rate depends on the porous structure of carriers and decreases with pore diameter decreasing.

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How to Cite

(1)
Kozakevych, R. B.; Yanishpolskii, V. V.; Tertykh, V. A. Effect of Porous Structure of Silica Carriers and Diclofenac State on Kinetics of Active Substance Release. Him. Fiz. Tehnol. Poverhni 2011, 2, 470-474.

Issue

Vol. 2 No. 4 (2011): Chemistry, Physics and Technology of Surface / Himia, Fizika ta Tehnologia Poverhni

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