Сoatings Based on Hydroxyapatite, Chitosan, and Silver for Biomedical Application

Authors

  • G. O. Yanovska Institute of Applied Physics of National Academy of Sciences of Ukraine
  • V. M. Kuznetsov Institute of Applied Physics of National Academy of Sciences of Ukraine
  • O. S. Stanislavov Institute of Applied Physics of National Academy of Sciences of Ukraine
  • V. Yu. Illiashenko Institute of Applied Physics of National Academy of Sciences of Ukraine

Abstract

Hydroxyapatite coatings containing silver are very promising due to their antimicrobial properties. Their application allows to decrease the possibility of contamination in the contacting area of implant with surrounding tissues. The aim of the work is deposition of coatings containing both inorganic (Ag) and organic (chitosan) components and estimation of silver concentration in the obtained coatings by atomic absorption spectroscopy. The coatings of hydroxyapatite with addition of silver were obtained on Ti6Al4V substrates by thermal deposition method. Adding chitosan to the initial solution allows to increase silver concentration in the coatings obtained.

References

Nair L.S., Laurencin C.T. Silver nano-particles: synthesis and therapeutic applications // J. Biomed. Nanotechnol. – 2007. – V. 3. – Р. 301–316.

Betts A. J., Dowling D. P., McConnell M. L., Pope C. The influence of platinum on the performance of silver-platinum antibacterial coatings // Mater. Design. – 2005. – V. 26. – P. 217–222.

Kawashita M., Tsuneyama S., Miyaji F. et al. Antibacterial silver-containing silica glass prepared by sol–gel method // Biomaterials. – 2000. – V. 21. –P. 393–398.

Zhao Q., Liu Y., Wang C. Development and evaluation of electroless Ag-PTFE composite coatings with antimicrobial and anticorrosion properties // Appl. Surf. Sci. – 2005. – V. 252. – P. 1620–1627.

Коновалова В.В., Побегай А.А., Брык М.Т. и др. Исследование антимикробных свойств мембран, модифицированных хитозаном // Серия Критические технологии. Мембраны. – 2006. – T. 32, № 4. – C. 56–61.

Chen Yi Kai, Zheng Xue Bin, Li Baoe et al. In vitro cytocompatibility of silver-containing hydroxyapatite coatings // Mat. Sci. Forum. – 2009. – V. 620–622. – P. 567–570.

Chen W., Liu Y., Courtney H.S. et al. In vitro antibacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating // Biomaterials. – 2006. – V. 27, N 32. – P. 5512–5517.

Chen W., Oh S., Ong A.P. et al. Antibacterial and osteogenic properties of silver-containing hydroxyapatite coatings produced using a sol gel process // J. Biomed. Mat. Research. A. – 2007. – V. 82, N 4. – P. 899–906.

Ghani Y., Coathup M.J., Hing K.A. et al. Development of a hydroxyapatite coating containing silver for the prevention of peri-prosthetic infection // J. Orthop. Res. – 2012. – V. 30, N 3. – P. 356–363.

Noda I., Miyaji F., Ando Y. et al. Next generation antibacterial hydroxyapatite coating: antibacterial activity of Ag ions in serum // Bioceramics Devel. Appl. – 2011. – V. 1. – P. 101–102.

Yonekura Y, Miyamoto H, Shimazaki T. et al. Osteoconductivity of thermal-sprayed silver-containing hydroxyapatite coating in the rat tibia // J. Bone Joint Surg. Br. – 2011. – V. 93, N 5. – P. 644–649.

Chung R.-J., Hsieh M.-F., Huang K.-C. et al. Antimicrobial hydroxyapatite particles synthesized by a sol-gel route // J. Sol-Gel Sci. Techn. – 2005. – V. 33, N 2. – P. 229–239.

D´ıaz M., Barba F., Miranda M. et al. Synthesis and antimicrobial activity of a silver-hydroxyapatite nanocomposite // Journal of Nanomaterials. – 2009. – V. 11, N 55. – P. 498–505.

Ding Y., Leng Y., Lu X. et al. Nano-Ag-loaded hydroxyapatite coatings on titanium surfaces by electrochemical deposition // J. R. Soc. Interface. – 2010. – Published online 29 September. – P. 1–11.

Liu R.F., Xiao X.F., Xu D.X. Composite electrodepositing HA/Ag bioceramic coatings // J. Chin. Ceram. Soc. – 2003. – V. 31. – P. 616–619.

Liu R.F., Xiao X.F., Zhen L.Q. et al. HA/Ag composite coatings prepared by two-step electrodeposition // Chin. J. Appl. Chem. – 2003. – V. 20. – P. 547–551.

Bai X., More K., Rouleau C.M. et al. Functionally graded hydroxyapatite coatings doped with antibacterial components // Acta Biomater. –2010. – V. 6. – P. 2264–2273.

Яновская А.А., Кузнецов В.Н., Данильченко С.Н. и др. Получение однородных покрытий на основе гидроксиапатита методом термо-депозиции // Біофізичний вісник. – 2010. – Вип. 25 (2). – С. 131–143.

Bragg P.D., Rainnie D.J. The effect of silver ions on the respiratory chain of Escherichia coli // Can. J. Microbiol. – 1974. – V. 20. – P. 883–889.

Chambers C.W., Proctor C.M., Kablar P.W. Bactericidal effect of low concentrations of silver // J. Am. Water. Works Assoc. – 1962. – V. 54. – P. 208–216.

Huang H.Z., Yang X.R. Synthesis of polysaccharide-stabilized gold and silver nanoparticles: a green method // Carbohyd. Res. – 2004. – V. 339. – 2627–2631.

How to Cite

(1)
Yanovska, G. O.; Kuznetsov, V. M.; Stanislavov, O. S.; Illiashenko, V. Y. Сoatings Based on Hydroxyapatite, Chitosan, and Silver for Biomedical Application. Him. Fiz. Tehnol. Poverhni 2012, 3, 346-351.