Peculiarities of Thermal Destruction of para-Aminosalicylic Acid in Binary Systems with ?-Cyclodextrin

Authors

  • L. A. Belyakova Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • N. V. Roik Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • L. S. Dzyubenko Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • T. V. Kulik Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • B. B. Palyanytsya Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine

Abstract

Thermal degradation of para-aminosalicylic acid in binary systems with ?-cyclodextrin has been studied. It was found that destruction of aromatic amino acid in equimolar physical mixture (or ”?-cyclodextrin – para-aminosalicylic acid” inclusion complex of 1:1) begins with decarboxylation reaction. Then the oxidative degradation of m-aminophenol and ?-cyclodextrin takes place. Temperatures of para-aminosalicylic acid decarboxylation and oxidative degradation of meta?aminophenol rise from para?aminosalicylic acid and its physical mixture with ?-cyclodextrin to equimolar ”?-cyclodextrin – para-aminosalicylic acid” inclusion complex. It was proved that the increase in thermal stability of the encapsulated para-aminosalicylic acid is mainly due to nonspecific interactions between hydrophobic cavity of cyclic oligosaccharide and aromatic ring of amino acid.

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(1)
Belyakova, L. A.; Roik, N. V.; Dzyubenko, L. S.; Kulik, T. V.; Palyanytsya, B. B. Peculiarities of Thermal Destruction of Para-Aminosalicylic Acid in Binary Systems With ?-Cyclodextrin. Him. Fiz. Tehnol. Poverhni 2013, 4, 37-46.

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Vol. 4 No. 1 (2013): Chemistry, Physics and Technology of Surface / Himia, Fizika ta Tehnologia Poverhni

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