Синтез та властивості нанокомпозитів Fe3O4/гідроксіапатит/памідронова кислота/ діетилентриамінпентаоцтова кислота/Gd3+

Ie. V. Pylypchuk; Yu. O. Zubchuk; A. L. Petranovskaya; S. P. Turanska; P. P. Gorbyk

doi:10.15407/hftp06.03.326

Authors

Ie. V. Pylypchuk Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
Yu. O. Zubchuk Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
A. L. Petranovskaya Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
S. P. Turanska Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
P. P. Gorbyk Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine

DOI:

https://doi.org/10.15407/hftp06.03.326

Keywords:

magnetite nanoparticles, gadolinium, diethylenetriaminepentaacetic acid, pamidronic acid, neutron capture therapy

Abstract

The novel Gd- containing magnetically sensitive nanocomposites were synthesized using the single-domain magnetite (Fe3O4), hydroxyapatite (HA), pamidronic acid (PA), diethylenetriaminepentaacetic acid (DTPA), gadolinium. We attached constituents sequentially to the surface of the compound that was synthesized in the previous reaction. Finally we synthesized nanocomposite Fe3O4/hydroxyapatite (HA)/ pamidronic acid (PA)/diethylenetriaminepentaacetic acid (DTPA)/gadolinium (Gd). Сomposition and structure of the nanocomposites were studied by FTIR spectroscopy, XRD and NMR. The synthesized nanocomposites can be used in medicine and biology, particularly in neutron capture therapy. They can serve as a multifunctional radio therapeutic drugs and diagnostic tools for targeted delivery, accumulation and retention of an external magnetic field.

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