Interaction of Red Blood Cells with Fumed SiO<sub>2</sub>, Al<sub>2</sub>O<sub>3</sub>/SiO<sub>2</sub> and TiO<sub>2</sub>/SiO<sub>2</sub> by Light Scattering Measurements

Authors

  • I. I. Gerashchenko Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • V. M. Gun'ko Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • V. I. Zarko Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • B. I. Gerashchenko Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology of National Academy of Sciences of Ukraine
  • L. S. Andriyko Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • V. F. Gorchev Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine

Abstract

The interaction of human red blood cells (RBCs) with fumed silica and fumed X/SiO2 (X = Al2O3, TiO2) at different concentrations of X oxide was studied by flow cytometry and photon correlation spectroscopy. The light scattering of RBCs affected by oxides in conjunction with the hemolysis degree showed that mixed oxides (X/SiO2), in general, had less membranotoxic effect than pure silica. The interaction of RBCs with fumed silica and other mixed oxides is a convenient model to examine membranotoxicity and biocompatibility of disperse materials. Flow cytometry and photon correlation spectroscopy are informative methods to study the mechanism of hemolysis induced by solid micro- or nanoparticles.

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How to Cite

(1)
Gerashchenko, I. I.; Gun’ko, V. M.; Zarko, V. I.; Gerashchenko, B. I.; Andriyko, L. S.; Gorchev, V. F. Interaction of Red Blood Cells With Fumed SiO<sub>2< sub>, Al<sub>2< sub>O<sub>3< sub> SiO<sub>2< sub> and TiO<sub>2< sub> SiO<sub>2< sub> By Light Scattering Measurements. Him. Fiz. Tehnol. Poverhni 2010, 1, 457-464.

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Vol. 1 No. 4 (2010): Chemistry, Physics and Technology of Surface / Himia, Fizika ta Tehnologia Poverhni

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