Effect of Organic Solvents and Doxorubicin on Clusterization of Water Bonded by DNA

Authors

  • V. V. Turov Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • V. F. Chekhun Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology of National Academy of Sciences of Ukraine
  • V. M. Gun'ko Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • V. M. Barvinchenko Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • S. V. Chekhun Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • A. V. Turov Taras Shevchenko National University of Kyiv

Abstract

Water bounded by DNA molecules is in several states corresponding to strongly associated water (SAW), two types of weakly associated water (WAW) and crystallizing water bound to basic sites. Weakly polar chloroform medium stabilizes the forms of weakly associated water but addition of polar DMSO inhibits the formation of one of WAWs. Intercalation of hydrated DNA molecules by doxorubicin diminishes the amounts of WAW and enhances of SAW contribution.

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(1)
Turov, V. V.; Chekhun, V. F.; Gun’ko, V. M.; Barvinchenko, V. M.; Chekhun, S. V.; Turov, A. V. Effect of Organic Solvents and Doxorubicin on Clusterization of Water Bonded by DNA. Him. Fiz. Tehnol. Poverhni 2010, 1, 465-472.

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Vol. 1 No. 4 (2010): Chemistry, Physics and Technology of Surface / Himia, Fizika ta Tehnologia Poverhni

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