Incorporation of gold nanoparticles by in situ and ex situ methods into hybrid hydrogels for medical purposes
DOI:
https://doi.org/10.15407/hftp16.04.508Keywords:
hydrogels, polyvinylformal, sponge, implants, gold nanoparticles, reconstructive surgery, orbital injuriesAbstract
Polymer hydrogels occupy a special place among the materials currently used for implant manufacturing due to their structural similarity to the macromolecular components found in the human body. However, traditional hydrogels often have insufficient mechanical strength, biocompatibility and biological activity. To overcome these limitations, we have developed methods for synthesising composite hybrid hydrogels based on porous polyvinylformal and gold nanoparticles. The physical and chemical properties of these hydrogels have been shown to depend on the synthesis strategy employed for the composite material, as well as on the type and synthesis method of the nanoparticles that it contains.
The morphology of the synthesized hybrid hydrogels (based on Polyvinylformal and gold nanoparticles, incorporated by in situ and ex situ methods) was investigated by means of electron microscopy (SEM), while their chemical structure was confirmed by Fourier Transform Infrared Spectroscopy (FTIR). The elemental composition of the synthesised polymer nanocomposites was investigated using energy-dispersive X-ray spectroscopy (EDX), while their thermostability and thermolysis processes were analysed using thermogravimetric analysis (TG, TGA and DTG studies). The swelling kinetics of hybrid gels with incorporated gold nanoparticles in water, the rate of diffusion of incorporated anticancer preparation DOXrubicin and bactericide Albucide, as well as their acute toxicity using in vitro experiments, were studied.
The synthesised composite hybrid hydrogels, which are based on porous polyvinyl formal and gold nanoparticles, show great promise as implants for reconstructive surgery in the oculo-orbital region. They can also be used to fill postoperative cavities after tumour resection, ensuring sterility of the surgical field and preventing tumour recurrence.
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