Role of components in aggregate and structure formation in multicomponent “Coagulox_N” dispersions

V.A. Prokopenko; A.V. Panko; O.A. Tsyhanovych; I.V. Zatovsky; S.M. Dybkova; L.S. Rieznichenko

doi:10.15407/hftp16.04.590

Authors

V.A. Prokopenko F.D. Ovcharenko Institute of Biocolloidal Chemistry of National Academy of Sciences of Ukraine
A.V. Panko F.D. Ovcharenko Institute of Biocolloidal Chemistry of National Academy of Sciences of Ukraine
O.A. Tsyhanovych F.D. Ovcharenko Institute of Biocolloidal Chemistry of National Academy of Sciences of Ukraine
I.V. Zatovsky F.D. Ovcharenko Institute of Biocolloidal Chemistry of National Academy of Sciences of Ukraine
S.M. Dybkova F.D. Ovcharenko Institute of Biocolloidal Chemistry of National Academy of Sciences of Ukraine
L.S. Rieznichenko F.D. Ovcharenko Institute of Biocolloidal Chemistry of National Academy of Sciences of Ukraine

DOI:

https://doi.org/10.15407/hftp16.04.590

Keywords:

mineral dispersed materials, colloidal interactions, zeta potential, structure formation, silica, metakaolin, walnut extract, gold and silver nanoparticles, alcoholic extract of unripe walnut, medical composition

Abstract

The diverse applications of dispersed polymineral composites in liquid dispersion media of various types require detailed investigation of the interactions between their components, in order to predict system stability and maintain the necessary physicochemical characteristics. Within the framework of the present study, we analyze the results of the mutual influence of the components of the topical experimental wound-healing, antimicrobial, and hemostatic agent Сoagulox_N, which is based on metakaolin, highly dispersed silica (A-300), a plant water-ethanol extract (unripe walnut fruits), and silver and gold nanoparticles. The experimental data obtained are based on measurements of aggregate (particle) size, ?-potential, rheological, and structural-mechanical characteristics for single- and multiphase aqueous and aqueous-ethanolic systems using a range of modern research methods. The influence of cationic surfactants and several other functional factors on the aggregative stability, structural-mechanical properties, and their controllability in the studied compositions is also considered. It is shown that the aggregation of metallic nanoparticles (silver and gold) occurs already at the stage of their preparation, after which they behave as separate binary phases. The mineral components of the composition form both individual and mixed aggregates of considerable size. In combination, the high values of rheological parameters and their ratios confirm the pronounced thixotropy and plasticity of the developed systems, which meet the requirements for such biomedical materials. Thus, the obtained results make it possible to propose approaches for creating a new stable mineral gel-like medicinal composition with complex action and to outline ways for further improvement of similar systems.

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