Chemistry, Physics and Technology of Surface, 2010, 1 (4), 465-472.

Effect of Organic Solvents and Doxorubicin on Clusterization of Water Bonded by DNA



V. V. Turov, V. F. Chekhun, V. M. Gun'ko, V. M. Barvinchenko, S. V. Chekhun, A. V. Turov

Abstract


Water bounded by DNA molecules is in several states corresponding to strongly associated water (SAW), two types of weakly associated water (WAW) and crystallizing water bound to basic sites. Weakly polar chloroform medium stabilizes the forms of weakly associated water but addition of polar DMSO inhibits the formation of one of WAWs. Intercalation of hydrated DNA molecules by doxorubicin diminishes the amounts of WAW and enhances of SAW contribution.

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Copyright (©) 2010 V. V. Turov, V. F. Chekhun, V. M. Gun'ko, V. M. Barvinchenko, S. V. Сhekhun, A. V. Turov

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