A Quantum Chemical Study on Levomycetin Interaction with Silica Surface

Authors

  • A. A. Kravchenko Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • T. V. Krupska Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • E. M. Demianenko Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • A. G. Grebenyuk Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • V. S. Kuts Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine
  • V. V. Lobanov Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine

Abstract

The biological activity of D(-)-threo-isomer of levomycetin is connected with presence of hydrogen bonding between hydroxyl groups of its alicyclic form. When grafted on silica surface (via impregnation), levomycetin increases its antimicrobial capability. Adsorption-induced changes in the structure and energy parameters of levomycetin molecules probably responsible of its activity have been studied by means of quantum chemistry. It has been found that descriptors of levomycetin bioactivity can be values of the LUMO energy and O-H…O hydrogen bond length within the propanediol fragment of the molecule.

References

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How to Cite

(1)
Kravchenko, A. A.; Krupska, T. V.; Demianenko, E. M.; Grebenyuk, A. G.; Kuts, V. S.; Lobanov, V. V. A Quantum Chemical Study on Levomycetin Interaction With Silica Surface. Him. Fiz. Tehnol. Poverhni 2010, 1, 242-247.

Issue

Vol. 1 No. 3 (2010): Chemistry, Physics and Technology of Surface / Himia, Fizika ta Tehnologia Poverhni

Section

Articles

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