Chemistry, Physics and Technology of Surface, 2010, 1 (3), 242-247.

A Quantum Chemical Study on Levomycetin Interaction with Silica Surface



A. A. Kravchenko, T. V. Krupska, E. M. Demianenko, A. G. Grebenyuk, V. S. Kuts, V. V. Lobanov

Abstract


The biological activity of D(-)-threo-isomer of levomycetin is connected with presence of hydrogen bonding between hydroxyl groups of its alicyclic form. When grafted on silica surface (via impregnation), levomycetin increases its antimicrobial capability. Adsorption-induced changes in the structure and energy parameters of levomycetin molecules probably responsible of its activity have been studied by means of quantum chemistry. It has been found that descriptors of levomycetin bioactivity can be values of the LUMO energy and O-H…O hydrogen bond length within the propanediol fragment of the molecule.

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References


Medicinal Chemistry and Clinical Application of Silicon Dioxide / Ed. А.А. Chuiko. – Kyiv: Naukova Dumka, 2003. – 415 p. (in Russian).

Krupska Т.V., Barvinchenko V.М., Kas­peskiy V.A. et al. Adsorption fixing levomycetin on high disperse silica surface // Farm. Zhurn. – 2006. – N 2. – P. 59–63. (in Ukrainian).

Krupska Т.V., Barvinchenko В.М., Grigoryeva М.А. et al. Study on vital activity and growth of biomass of unicellular microorganisms in presence of high disperse silica and modified silicas // Farm. Zhurn. − 2008. − N 1. − P. 59−64. (in Ukrainian).

Chemistry and Biology: at the Joint of Two Sciences / Ed. V.Т. Ivanov. – Мoscow: Nauka, 2006. – 264 p. (in Russian).

Mechanism of Antibiotics Action / Ed. G.F. Gause. – Мoscow: Mir, 1969. – 720 p. (in Russian).

Molecular Principles of Antibiotics Action / Ed. G.F. Gause. – Мoscow: Mir, 1975. – 500 p. (in Russian).

Chemistry of Antibiotics / Ed. М.М. Shemyakin. – Мoscow: Publishers АS SSSR, 1961. – V. 1 – 616 p. (in Russian).

Ivanov V.V, Sleta L.А. Computing Methods of Prognosis of Biological Activity of Organic Compounds. – Kharkov: KNU, 2003. – 71 p. (in Russain).




Copyright (©) 2010 A. A. Kravchenko, T. V. Krupska, E. M. Demianenko, A. G. Grebenyuk, V. S. Kuts, V. V. Lobanov

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