Chemistry, Physics and Technology of Surface, 2015, 6 (3), 326-335.

Synthesis and properties of Fe3O4/hydroxyapatite/pamidronic acid/diethylenetriaminepentaacetic acid/Gd3+ nanocomposites



DOI: https://doi.org/10.15407/hftp06.03.326

Ie. V. Pylypchuk, Yu. O. Zubchuk, A. L. Petranovskaya, S. P. Turanska, P. P. Gorbyk

Abstract


The novel Gd- containing magnetically sensitive nanocomposites were synthesized using the single-domain magnetite (Fe3O4), hydroxyapatite (HA), pamidronic acid (PA), diethylenetriaminepentaacetic acid (DTPA), gadolinium. We attached constituents sequentially to the surface of the compound that was synthesized in the previous reaction. Finally we synthesized nanocomposite Fe3O4/hydroxyapatite (HA)/ pamidronic acid (PA)/diethylenetriaminepentaacetic acid (DTPA)/gadolinium (Gd). Сomposition and structure of the nanocomposites were studied by FTIR spectroscopy, XRD and NMR. The synthesized nanocomposites can be used in medicine and biology, particularly in neutron capture therapy. They can serve as a multifunctional radio therapeutic drugs and diagnostic tools for targeted delivery, accumulation and retention of an external magnetic field.

Keywords


magnetite nanoparticles; gadolinium; diethylenetriaminepentaacetic acid; pamidronic acid; neutron capture therapy

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DOI: https://doi.org/10.15407/hftp06.03.326

Copyright (©) 2015 Ie. V. Pylypchuk, Yu. O. Zubchuk, A. L. Petranovskaya, S. P. Turanska, P. P. Gorbyk

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