Chemistry, Physics and Technology of Surface, 2015, 6 (4), 481-488.

Adsorption of doxorubicin by fumed silica and magnetite/siloxane nanocomposites



DOI: https://doi.org/10.15407/hftp06.04.481

A. L. Petranovska, A. P. Kusyak, Ie. V. Pylypchuk, P. P. Gorbyk

Abstract


A technique has been developed for immobilization of the cytostatic drug doxorubicin on the surface of magnetite nanoparticles modified with biocompatible siloxane coating and fumed silica. The processes of adsorption/desorption of doxorubicin at given surfaces were studied, high adsorption activity of siloxane surface of nanocomposites was determined with respect to doxorubicin. New nanocomposites magnetite/siloxane/doxorubicin synthesized may be promising for use in oncology, in creating the remedies for targeted delivery of drugs and as adsorption materials for intracorporal and extracorporal detoxification of the organism.

Keywords


modification; biocompatible coatings; silica; adsorption; doxorubicin

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DOI: https://doi.org/10.15407/hftp06.04.481

Copyright (©) 2015 A. L. Petranovska, A. P. Kusyak, Ie. V. Pylypchuk, P. P. Gorbyk

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